Category Archives: DAT

Although chemokine-induced immune responses can act to eliminate pathogens, they may also be responsible for neuronal damage and are involved in the pathogenesis of a number of diseases of the CNS that are associated with inflammation and neurodegeneration diseases (Bajetto et al., 2002; Miller et al., 2008). investigate interactions of JCV with its host cells. Results show that contamination with JCV delays oligodendrocyte maturation as shown by reduced levels of oligodendrocytic markers, including myelin basic protein, proteolipid protein, and platelet-derived growth factor receptor-. Furthermore, replication of JCV in these cells caused substantial dysregulation of several chemokines, including CCL5/RANTES, GRO, CXCL1/GRO, CXCL16, CXCL8/IL-8, CXCL5/ENA-78, and CXCL10/IP-10, all of which play a role in cell growth and differentiation. strong class=”kwd-title” Keywords: neural progenitor, polyomavirus, progressive multifocal leukoencephalopathy Progressive multifocal leukoencephalopathy (PML), which is usually caused by the human polyomavirus JC (JCV), remains a fatal disease despite recent advances. JCV contamination occurs during…

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Parental ZMEL1-GFP cells maintained in tradition were also subject to FACS sorting, and gene expression profiling was performed on the two cell populations. (C) Ingenuity Pathway Analysis of ZMEL1-GFP cells after metastatic dissemination suggests seven pathways that could mediate microenvironmental effects on melanoma growth. the tumor cell surface. Among the six FATP/SLC27A family members, melanomas significantly overexpress FATP1/SLC27A1. Melanocyte-specific FATP1 manifestation cooperates with BRAFV600E in transgenic zebrafish to accelerate melanoma development, an effect that is similarly seen in mouse xenograft studies. Pharmacologic blockade of FATPs with the small Benfluorex hydrochloride molecule Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion. These data demonstrate that stromal adipocytes can travel melanoma progression through FATP lipid transporters, and represents a new target aimed at interrupting adipocyte-melanoma cross-talk. Statement of Significance We demonstrate that stromal adipocytes are donors of lipids that mediate melanoma progression. Adipocyte-derived lipids are taken up by…

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